IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?

Efficacy Enhanced by an Anti-IL-2 mAb IL-2 In Vivo Activities and Antitumor

IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb.

IL-2 is a potent immunostimulant and has been tested for clinical use, including in immunotherapy for cancers and HIV infection. Here we show that a widely used neutralizing anti-murine IL-2 mAb (S4B6) exhibits unexpected activities that enhance the treatment effects of IL-2 in vivo. Coinjection of the anti-IL-2 mAb with a plasmid carrying murine IL-2 cDNA significantly increased the serum IL-2...

A COMPARISON OF IL-2 IN NORMAL AND SYMPTOMATIC PULPS

Normal healthy pulpal tissues were obtained from 19 impacted molars and symptomatic samples were obtained from 18 carious molars and premolars clinically diagnosed in all vital pulpal tissues. Student's t-test revealed significant differences in IL-2 concentrations, comparing symptomatic pulpal tissues with normal healthy samples (657, p<O.OI). These results suggest that IL -2 may serve as...

Whole Tumor Cell Vaccine Adjuvants: Comparing IL-12 to IL-2 and IL-15

Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce pe...

The roles of IL-2, IL-7, and IL15 Ligands in B Cells development

Abstract Background B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as -common family have an essential cytokines may support either synergistically or in an additive m...